Pacing Project

Studying Different Pacing Patterns on Isolated Perfused Rabbit Hearts

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Purpose:


History:

What we are looking for:

Experimental Variables:

Pacing Protocol:
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Results
Cathodal vs. Anodal Pacing

 
 
 
 

p < 0.05


Cathodal/Anodal

Parameter

at 2 V
at 4 V
at 6 V
at 8 V
Pmax
1.02 (62 %)
0.97 (38 %)
0.97 (40 %)
0.93 (45 %)
P integral over one beat
0.98 (14 %)
0.96 (39 %)
0.98 (53 %)
0.89 (48 %)
dP/dt
0.98 (21 %)
0.97 (30 %)
0.97 (16 %)
0.95 (53 %)
Time delay Stim - Pmax
1.03 (31 %)
1.02 (45 %)
1.03 (56 %)
1.02 (62 %)
Conclusions

Future Plans:

Related papers:

1.  Thakral, A., Stein, L., Shenai, M., Gramatikov, B.I. and Thakor, N.V.  Effects of Anodal versus Cathodal Pacing on the Mechanical Performance of the Isolated Rabbit Heart.    Journal of Applied Physiology, Vol. 89, Issue 3, 1159-1164, September 2000.

2. Thakral, A., Stein, L., Shenai, M., Gramatikov, B., Thakor, N. and Mower, M. Effects of varying the pacing waveform on mechanical performance in the rabbit heart. Pace, Vol.22, April 1999, Part II, p.750 (Abstracts of the 20th Annual Scientific Sessions of the North American Society of Pacing and Electrophysiology, NASPE, Toronto, May 12-15, 1999).

3. Thakral, A., Stein, L., Shenai, M., Gramatikov, B., Thakor, N. and Mower, M. Comparison of anodal vs. cathodal pacing patterns in isolated Langendorff perfused rabbit hearts. Abstracts of the Biomedical Engineering Society 1998 Annual Fall Meeting, 10-13 October 1998, Cleveland, OH. In Annals of Biomedical Engineering, Vol. 26, Suppl. 1, p. S-22, Abstract CB.46.
 


This page was created by Boris Gramatikov

Last update: November, 2000