ADVANCED 2-DIMENSIONAL COMPUTER MODELING OF MYOCARDIAL ISCHEMIA

Table of Contents

Manifestations of Myocardial Ischemia

Manifestations of Myocardial Ischemia at the Cellular Level

Myocardial Ischemia - Hyperkalemia

Myocardial Ischemia - Acidosis

Myocardial Ischemia - Anoxia

Myocardial Ischemia - Integrated Model

Computer Modeling of Ischemia

Computer Modeling of Ischemia

LUO-RUDY MODEL (1-cell)

LUO-RUDY Model (1-cell)

L-R Extension to 2-Dimensions

Cluster Model

Numerical Integration 

Numerical Integration

Reconstructing the Lead Potential

Modeling Myocardial Ischemia

Isopotential maps: Normal vs. Ischemia (t=17.5 ms)

Isopotential maps: Normal vs. Ischemic (t=25 ms)

Isopotential maps: Normal vs. Ischemic (t=40 ms)

Isopotential maps: Normal vs. Ischemia (t=80 ms)

Effect of ischemia on Action Potentials

Analytical Methods

Continuous Wavelet Transform of a unipolar signal at point (13,15) - contour plot

Continuous Wavelet Transform of a unipolar signal at point (13,15) - 3D plot

Related papers:

1. Shenai M., Gramatikov, B.I., Thakor, N.V. Computer models of depolarization alterations Induced by myocardial ischemia. The effect of superimposed ischemic inhomogeneities on propagation in space and time-frequency domains.  Journal of Biological Systems, Vol. 7, No.4, 1999,  pp. 553-574.

2. Thakor, N.V., Ferrero, J.M.Jr., Saiz, J., Gramatikov, B., Ferrero, J.M. Sr.  Electrophysiologic models of heart cells and cell networks. IEEE Engineering in Medicine and Biology, Vol. 17, No.5, Sept./Oct. 1998, pp. 73-83.

3. Shenai, M., Gramatikov, B., Thakor, N.V. Computer modeling of depolarization changes induced by myocardial ischemia. Computers in Cardiology 1998, Vol. 25, Cleveland, Ohio, Sept.13-16, 1998. pp. 321-324.