Computer Modeling of ischemic depolarization of myocardial tissue (M. Shenai, B. Gramatikov, N.V.Thakor) - A study on the effects of local ischemia on isopotential maps, action potentials and integrated unipolar signals

Fibrillation detection and analysis (B. Gramatikov, M. Kremers, A. Casaleggio) - development of techniques related to external and implanted devices for fibrillation detection and defibrillation.

Ischemia detection (B. Gramatikov) - development of signal processing methods such as wavelet analysis to analyze ischemic ECG in stress testing and angioplasty procedures; click here for a presentation on ischemia detection during PTCA.

Langendorff experiments (L. Stein, A. Thakral, M. Shenai, B. Gramatikov)- on isolated rabbit hearts using the floating microelectrode and optical fluorescence imaging technique to study electrophysiological response in ischemia, fibrillation;

Electromechanical pacing on isolated rabbit hearts (L. Stein, A. Thakral, M. Shenai, B. Gramatikov) - experiments to enhance the mechanical response with different pacing stimuli.

Mechanical activation during cardiac pacing in open chest dog model (S. Rajasekhar) - Study of different stimulation waveforms using MRI imaging.

Modeling and simulation (M. Fishler, former PhD student) - mechanisms of arrhythmia (fibrillation, spiral wave) generation and termination modeled on a supercomputer:

successful spiral wave termination attempt
unsuccessful spiral wave termination attempt

Lab personnel:

Faculty: Boris Gramatikov, Ph.D.